Born just a couple miles from Clarksdale, Mississippi, in Riverton, Son House was born to a family with 17 children. Though, soon after, he moved to Tallulah, Louisiana at age 8, due to his parent's separation. Adapting to changes such as these, House soon became facinated by Sunday services he would attend. It wasn't long until his main aim at age 15 was to become a Baptist preacher. For the rest of his life, he'd have to balance his passion for religion with his indulgence for blues and a more Bohemian lifestyle.
In his 20s, Son House became inspired by musicians such as Willie Wilson and taught himself the guitar. Moving back to his hometown near Clarksdale, House had the opportunity to mix with the burgeoning blues scene of the time, playing together with contemporaries like Charley Patton, Willie Brown, and Leroy Williams. After brushing with the law around 1928 to 1929, shooting a man in self-defence, House attended the legendary Parchman Farm prison. Luckily he only had to serve for those 2 years, though was pushed to leave Clarksdale. Deciding to settle in Lula, Mississippi, nearby, he joined Charley Patton, who'd been similarly exiled from Clarksdale & Dockery Plantation around 1929 to 1930. Soon after, in 1930, House recorded for Paramount Records, supported by Charley Patton who vouched for him. The years that followed were mostly subdued, apart from another recording session with Alan Lomax from 1941 to 1942.
As with many pre-war blues musicians, the 1960s' Folk Revival gave a rebirth to Son House's musical career. Having lived in Rochester, New York since 1943 and working for New York's Central Railroad, he had no idea that his music was suddenly gaining popularity through his recordings' re-releases. New calls kept ringing, which led him to play such festivals as the Newport Folk Festival in 1964, the New York Folk Festival in 1965, a European tour in 1967 with the American Folk Festival, and more European touring in 1970.
Ill health, exacerbated by a life of excess when it came to liquor, crept up on him in the mid-70s. Moving to Detroit, Michigan, he remained there until his death in 1988.