Born in Centerville, Texas, Hopkins was immersed in the finest blues music from a young age. With great fortune, by the time he was just 8, he found that the church his family attended was also attended regularly by none other than Texas blues legend Blind Lemon Jefferson. Quickly, Jefferson must have seen something different in the young Hopkins because, soon after, Jefferson began mentoring Hopkins at these church gatherings. On top of this exposure and learning, Hopkins' older cousin was Texas Alexander, one of the early recorded blues musicians, and one of his other cousins was Frankie Lee Sims, another well known blues musician.
Both the 30s and 40s were tough decades for Hopkins, from his eyes most likely. In the 30s, he landed in Houston County Prison Farm, and was upon his release unsuccessful in breaking into Houston's music scene. Going back to his home town, Centerville, to earn income on the farms, he remained working there, also playing music on the side, through the 40s. Finally, he caught a break and was recorded by Aladdin Records in 1946, which led him to Los Angeles to record.
A steady rise from through the following years led to Hopkins being a big name by the mid 50s. As the times shifted even more into his favour in the 1960s, with the Folk Revival, Hopkins' career truly exploded, until he's now become among the best recorded blues musicians (in terms of number of albums recorded). With his reach, he influenced many guitarists; for example, Jimi Hendrix's family listened to much blues, and one of young Hendrix's favorites happened to be Lightnin' Hopkins. Never straying far from his Texas roots, Hopkins died in Houston in 1982, at the age of 69.